"Sato", our main character, is oppressed by his social inability to go out of his apartment. Other wise known as a "Neet".
"Yamazaki" has absolutely no luck with women (though I don't know why, he's adorable and passionate) and seems to chose his potential dates poorly.
"Misaki" is a most beautiful person even if she's shy and reserved. She has a vulnerable aspect that makes you want to hug her.
Sato sees people as monsters whenever he steps out of his one room studio, but I believe his deep rooted problem is his feelings of inadequacy of himself and life in general. He's the worst case scenario type of collage drop-out with a negative crit damage everytime he steps out the door.
Misaki, our heroine, is the only person who seems to understand Sato and want to help him. But she has feelings of her own inadequacy that halt these two from getting into a romantic relationship.
In the background, Sato and Yamazaki are working on a "gal-game" together so Sato can impress upon Misaki that he's not a hikikomori. But she sees through his lies.
When Sato does go out of his house the results are disastrous in one form or another that makes me cackle my head off.
You can always watch Sato and know your life isn't that bad. Alternatively you can watch the craziness that ensues when a "hikikomori" tries to reconcile with the outside world. It's a great way to laugh at the human condition.